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Supplementary tables - Role of nucleic acid-based polymeric micelles in treating lung diseases

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posted on 2023-01-06, 10:11 authored by Jaskiran Kaur, Monica Gulati, Leander Corrie, Ankit Awasthi, Niraj Kumar Jha, Dinesh Kumar Chellappan, Gaurav Gupta, Ronan MacLoughlin, Brian G Oliver, Kamal Dua, Sachin Kumar Singh

The prevalence of lung diseases is increasing year by year and existing drug therapies only provide

symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative

therapeutic approach owing to their potential to reform a homeostatic balance by upregulating

protective genes or downregulating damaging genes. However, their inherent properties, such as poor

stability, ineffective cellular uptake, negative charge and so on, hinder their clinical utility. Such limitations

can be overcome by exploiting the functional chemistry of polymeric micelles (PMs) for site-specific

delivery, transfection efficiency and improved stability. With this objective, the present work describes

the advancements made in designing nucleic acid-based PMs for treating lung diseases followed by

approaches requiring consideration for clinical applications.


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