Supplementary materials - Combined serum CXCL8, CXCL9 and CXCL13 tests for the prediction of microvascular invasion in hepatocellular carcinoma.

Aim: This work is to explore the predictive and diagnostic value of chemokine C-X-C motif ligand 8 (CXCL8),

CXCL9 and CXCL13 combined detections for microvascular invasion (MVI) in hepatocellular carcinoma

(HCC) patients. Materials & methods: A total of 82 HCC patients with MVI were recruited as the MVI

group and 154 patients with non MVI were recruited as the non MVI group. Results: In HCC patients with

MVI, CXCL8, CXCL9, CXCL13 levels were significantly elevated. Child–Pugh scores and serum α-fetoprotein

level had positive correlation with CXCL8, CXCL9 and CXCL13 levels. The serum levels of CXCL8, 9 and 13

were effective in predicting MVI in HCC patients. Conclusion: CXCL8, CXCL9 and CXCL13 levels in HCC

patients are valuable parameters in the prediction of MVI.