Supplementary data.pdf (4.8 MB)

Supplementary data: Synthesis and biological evaluation of oleanolic acid derivatives with electrophilic warheads as antitumor agents

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posted on 2023-05-25, 15:39 authored by Shisheng Wang, Dongxue Yang, Xiaorui Li, Sen Cai, Ning Deng, Guangdong Wang, Tao Sun, Yueqing Li, Guangzhe Li, Xiuhan Guo

Supplementary data

Funding

This study was supported by the Fundamental Research Funds for the Central Universities of China (DUT21YG124), Science and Technology Innovation Fund of Dalian (2022JJ13SN073), and Natural Science Foundation of Liaoning Province (2022-YGJC), Large Instrument Open Fund of Dalian University of Technology. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Keywords

antitumor apoptosis induction electrophilic warheads ferroptosis induction inhibition of Akt/mTOR pathway inhibition of GPX4 oleanolic acid derivatives

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CC BY-NC-ND 4.0