The Imagenetics Initiative and Sanford Chip Program and this work were supported by Sanford Health. KD Christensen was also supported by grant K01-HG009173 from the NIH. KD Christensen, ES Zoltick andMR Hickingbotham were supported by a research grant from Sanford Health. RC Green has received compensation for advising the following companies – AIA, Embryome, Genome Web, Genomic Life, Grail, Humanity, OptumLabs, Plumcare and Verily – and is co-founder of Genome Medical, Inc. C Hajek is an employee of Helix OpCo, LLC. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.