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Supplementary Tables – Generalizability of ORIENT-11 Trial Results to a US Standard of Care Cohort with Advanced Non-Small Cell Lung Cancer

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posted on 31.03.2022, 07:56 by Figshare Future Science GroupFigshare Future Science Group, Nagasaka, Misako, Molife, Cliff, Cui, Zhanglin, Stefanik, Victoria, Li, Xiaohong, Kim, Sangmi, Lee, Hsiu-Yung, Beyrer, Julie, Blumenschein, G

Supplementary Table 1. Baseline Assessment between target US population and ORIENT-11 SPP and PPP arms before and after Adjustmenta

Abbreviations: BMI, body mass index; ECOG PS, Eastern Cooperative Oncology Group performance status; EB, entropy balancing; IPW, inverse probability weighting; N, number of patients in population; n, number of patients in the specified category; PPP, placebo+pemetrexed+platinum; PD-L1, programmed death-ligand 1; SD, standard deviation; SPP, sintilimab+pemetrexed+platinum; SMD, standardized mean difference between SPP and Target US Population or between PPP and Target US Population

* Data from Yang et al. 2020

aAdjustment refers to IPW (primary analysis) and EB (sensitivity analysis)

b Age was recorded at first line start date

c Duration of disease was reported from advanced diagnosis to first line start date


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