Future Science Group
Browse
Supplementary_Table_2.xlsx (1.39 MB)

Supplementary Table 3 Differentially expressed mRNAs identified by RNA-seq

Download (1.39 MB)
dataset
posted on 2021-06-15, 13:41 authored by Taylor & FrancisTaylor & Francis, Chao Tan, Xi Zeng, Meile Mo, Xiaoyun Ma, Qiuli Liang, Wenjie Liang, Wenxiu Huang, Ke Wang, Li Yang, Xiaoqiang Qui

Aim: To explore the expression profiles of lncRNAs and identify novel lncRNAs as biomarkers for early diagnosis and therapy of hepatocellular carcinoma (HCC). Materials & methods: Expression profiles of lncRNAs and mRNAs in five paired HCC and adjacent normal tissues were obtained by RNA-seq. Eight lncRNAs, including two novel liver-specific lncRNAs (NONHSAT059247.2 and NONHSAT013897.2), were validated in another 74 pairs of HCC and adjacent normal tissues by qRT-PCR. Results: The results of qRT-PCR showed that NONHSAT252133.1, NONHSAT112116.2, and NONHSAT242657.1 were significantly upregulated in HCC tissues, whereas NONHSAT169790.1, NONHSAT059247.2, and NONHSAT013897.2 were significantly downregulated. Two liver-specific lncRNAs demonstrated excellent diagnostic performance: NONHSAT059247.2 (AUC=0.941, 95% CI: 0.902-0.979, P<0.0001), NONHSAT013897.2 (AUC=0.944, 95% CI: 0.906-0.983, P<0.0001).

Conclusion: The liver-specific lncRNAs NONHSAT059247.2 and NONHSAT013897.2, may provide new biomarkers for the future study on diagnosis, therapy, and mechanisms of HCC.

History

Usage metrics

    Biomarkers in Medicine

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC