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Supplementary Table 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing

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posted on 02.08.2021, 08:51 authored by Xianlin Yi, Chanzhen Liu, Juan Zhou, You Li, Haoyuan Lu, Yulei Lu, Wei Wei, Mingsong Wu

Supplement Table 1. The expression of genes in morning and evening

Abstract

Background: This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Materials & methods: Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors, and cholinergic signals were detected. Results: HIF-1α, VEGF, CD44, interleukin-6, and prominin 1 expression in canine urine after partial cystectomy exhibited two similar peaks at ~2 weeks. HIF-1α and VEGF expression was higher in the afternoon than in the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing. Conclusions: The expression of HIF-1α, VEGF, key stem cell transcription factors, and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.

Funding

This work was supported by the National Natural Science fund of China (31860289) (81760508).

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