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Supplementary Material: Body composition and inflammation impact in non-small cell lung cancer patients treated by first line immunotherapy

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posted on 21.10.2021, 08:05 by Cinzia Baldessari, Raffaella Marcheselli, Giorgia Guaitoli, Riccardo Bonacini, Filippo Valoriani, Annarita Pecchi, Pietro Torricelli, Linda Reverberi, Renata Menozzi, Giuseppe Pugliese, Maria Giuseppa Vitale, Roberto Sabbatini, Federica Bertolini, Fausto Barbieri, Massimo Dominici

Table 1 Supplementary Material. Study with mono-immunotherapy in first line in NSCLC: CheckMate 026 and Keynote 024

Table 2 Supplementary Material. Variation of blood exams and CT scan values from baseline to first re-staging°

Table 3 Supplementary Material. Correlation between different characteristics of patients

Table 4 Supplementary Material. Overall Survival Univariate analysis with baseline WBC, albumin, CRP and NLR considered as continuous variable and Multivariate analysis with WBC, albumin, SMI and VSR as continuous variables

Figure 1 Supplementary Material. Kaplan-Meier Overall Survival curves according to SFI and CRP variation

Figure 2 Supplementary Material. Selected CT scan parameters (3 for muscle mass and 3 for adipose tissue) in relation with response, comparing values at baseline and first re-staging

Figure 3 Supplementary Material: ROC curves and Kaplan Meier (KM) Overall Survival curves according to selected parameters. A: white blood cell (WBC), B: albumin, C: C-reactive protein (CRP). 1: ROC curves; 2: KM curves divided with cut-offs derived from ROC curves, 3: KM curves divided with median, 4: KM curves divided with selected cut-offs (upper normal limit (UNL) or low normal limit (LNL).

Figure 4 Supplementary Material: ROC curves and Kaplan Meier (KM) Overall Survival curves according to selected parameters. D: Neutrophil-to-lymphocyte ratio (NLR), E: Skeletal Muscle Index (SMI), F: Advance lung cancer inflammation index (ALI score). 1: ROC curves; 2: KM curves divided with cut-offs derived from ROC curves, 3: KM curves divided with median, 4: KM curves divided with selected cut-offs derived from literature (c.o.).

Figure 5 Supplementary Material. SMI, VSR, albumin and CRP at baseline in relation with response in our patients.

Figure 6 Supplementary Material. Relationship between classes of BMI and weight loss and mOS in our patients

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