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Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events. Supplementary Table 1

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posted on 2023-03-09, 09:54 authored by Yanfei HuoYanfei Huo, Yungang Lai, Qiang FengQiang Feng, Qingxiang Wang, Junhua Li

Aim: This study aimed to investigate the correlation of ITIH4with inflammatory cytokines, stenosis degrees

and prognosis in coronary heart disease (CHD) patients. Methods: Serum ITIH4 levels of 300 CHD patients

and 30 controls, together with levels of TNF-α, IL-6, IL-8 and IL-17A of CHD patients, were determined

using ELISA. Results: Serum ITIH4 was reduced in CHD patients versus controls (p < 0.001). ITIH4 was

negatively linked with TNF-α, IL-6, IL-8, IL-17A, C-reactive protein, serum creatinine and Gensini score

in CHD patients (all p < 0.050). ITIH4 quartile level negatively correlated with the cumulative major

adverse cardiovascular event rate (p = 0.041). Conclusion: Serum ITIH4 may serve as an anti-inflammatory

biomarker that negatively associates with stenosis degree and major adverse cardiovascular event risk in

CHD patients.