Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus: Supplementary figure.pdf

Partial alignment among genomes of the coronaviruses RaTG13 and SARS-CoV-2 (accession numbers are available in Table 1) and the nucleotide sequence of BtCoV/4991 (Genbank KP876546.1) [21]. The polypeptide sequence is reported under the nucleotide sequences. Alignment of the nucleotide sequences is shown until the end of motif C [24] (red). Cyan, polymorphisms between BtCoV/4991 and SARS-CoV-2; bold: codon responsible of the amino acid substitution H-to-Y occurring between RaTG13 and SARS-CoV-2 (in cyan); green: interacting residues of the palm domain according with Gao et al. [24].