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Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients: supplementary data

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posted on 2023-01-27, 10:04 authored by Luu Thi Thanh Duyen, Bui Van Manh, Tran Thi Phuong Thao, Le Van Khanh, Bui Ngoc Linh Trang, Ngo Truong Giang, Ha Van Quang, Nguyen Thanh Viet, Ngo Thu Hang, Can Van Mao, Nguyen Linh Toan, Hoang Van Tong

Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with

clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105

patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of

sepsis progression. Angiopoietin-2 levels were correlatedwithmean arterial pressure and platelets counts,

total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately

discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).

Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic

shock.

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