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Prevalence of occult hepatitis B infection in liver biopsy sample of patients with nonviral liver disease: Supplementary Figure and Table

posted on 2022-07-20, 08:33 authored by Bulent Cakal, Alp Atasoy, Bilger Cavus, Mehves Poda, Mesut Bulakci, Mine Gulluoglu, Mehmet Demirci, Filiz Akyuz

Aim: To determine the prevalence of occult hepatitis B (HBV) infection (OBI) in patients with nonviral

liver disease. Materials & methods: This study included 83 HBsAg-negative patients followed up at a

gastroenterohepatology clinic. The presence of HBV DNA was investigated by using an in-house nested-

PCR method applied to liver parenchymal biopsy samples obtained from patients who underwent due

nonviral chronic liver disease. Results: OBI was detected in 19 (22.9%) of the 83 cases, in 11 (44%) of 25

anti-HBc-positive patients, and 15 (31.9%) of 47 anti-HBc and/or anti-HBs antibodies-positive patients.

Conclusion: There is a considerable prevalence of OBI among patients with nonviral chronic liver disease.

Therefore, it is suggested that closely monitoring HBV can be useful to prevent or more effectively manage

possible OBI-related complications among patients with nonviral chronic liver disease, especially those

who are HBsAg seronegative or anti-HBV antibody seropositive.


This study was supported by the Scientific Research Projects Coordination Unit of Istanbul University with the project number TOA-2016-21643