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This work was supported by the Shanghai Sailing Program (21YF1443500), the Natural Science Foundation of Shanghai (23ZR1459500), the Natural Science Foundation of Fujian Province (2021D032), China Postdoctoral Science Foundation (2022M710756), National Natural Science Foundation of China (82202969), Youth Fund of Zhongshan Hospital Fudan University (LCBSHZX010) and the Shanghai Municipal Key Clinical Specialty (shslczdzk03202). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.