Future Science Group
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Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation supplementary dataset

posted on 2023-09-13, 10:47 authored by Nikita Kaushal, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Kamini Sharma, Ajay Sharma, Arya Lakshmi Marisetti, Madan Mohan Gupta, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalki, Gaurav Gupta

Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.