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Plasma cytokine profile in occult HBV-infected blood donors: supplementary materials

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posted on 2023-03-03, 14:07 authored by Qinghui Wang, Huizhong Qian, Xiao Liu, Jian Jiang, Qingqin Hao

Aim: Cytokine profile in occult HBV infection (OBI) was systematically investigated to identify the

immunopathogenesis of OBI. Materials & methods: A total of 46 OBI, ten asymptomatic hepatitis B surface

antigen carriers, ten chronic hepatitis B and 12 healthy blood donors were recruited. A total of 21 plasma

cytokines were detected. Results: Compared with healthy blood donors, elevated plasma Th1, Th2, Th17

and immune regulatory associated cytokines were observed in OBI. Almost no significant difference was

found for these cytokines among OBI, asymptomatic hepatitis B surface antigen carriers and chronic

hepatitis B. OBI displayed the predominance of type 2 and regulatory immunity. Conclusion: OBI displayed

the general cytokine profile of chronic HBV infection, which might contribute to virus persistence and

the presence of the liver microinflammatory environment. The clinical implications of OBI deserve more



This study was funded by the programs sponsored by Natural Science Foundation of Wuxi, China (no. Y20212038), Science Foundation of Wuxi Healthy Committee (no. M202166), Science Foundation of Jiangsu Society of Blood Transfusion (no. JS2020019), and the Top Talent Support Program for Young andMiddle-aged People ofWuxi Healthy Committee (no. HB2020101).


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