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Pharmacogenetic testing-guided treatment for oncology: an overview of reviews: Supplementary Data

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posted on 2022-08-24, 14:59 authored by Danilo Vieira de Lara, Daniela Oliveira de Melo, Daniele Y Kawakami, Thuane S Goncalves, Paulo CJL Santos

Pharmacogenetics is the relationship between an individual’s genetic variations and their response

to pharmacological treatment. We conducted an overview of reviews on the use of post-treatment

pharmacogenetic testing for oncology, based on clinically relevant gene–drug pairs. We conducted a

search on Medline, Embase and Cochrane Library, from their inception to 18 June 2020. We selected

six eligible systematic reviews. The most studied drug categories were estrogen agonists/antagonists

and fluoropyrimidines associated with cytochrome P450 and dihydropyrimidine dehydrogenase genes

(CYP2D6 and DPYD), but many studies were classified as being of critically low or low quality. There

is a need for more high-quality primary studies and systematic reviews that assess the risk of bias,

with consistent definitions of clinical outcomes to consider the benefits of pharmacogenetic testing for



141302/2020-8 – Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnolo´ gico (CNPQ); 001 – Coordenac¸a˜o de Aperfeic¸oamento de Pessoal de N´ıvel Superior (CAPES); 2019/08338-7 – Fundac¸a˜ o de Amparo a` Pesquisa do Estado de Sa˜ o Paulo (FAPESP).


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