Pharmacogenetic testing-guided treatment for oncology: an overview of reviews: Supplementary Data

Pharmacogenetics is the relationship between an individual’s genetic variations and their response

to pharmacological treatment. We conducted an overview of reviews on the use of post-treatment

pharmacogenetic testing for oncology, based on clinically relevant gene–drug pairs. We conducted a

search on Medline, Embase and Cochrane Library, from their inception to 18 June 2020. We selected

six eligible systematic reviews. The most studied drug categories were estrogen agonists/antagonists

and fluoropyrimidines associated with cytochrome P450 and dihydropyrimidine dehydrogenase genes

(CYP2D6 and DPYD), but many studies were classified as being of critically low or low quality. There

is a need for more high-quality primary studies and systematic reviews that assess the risk of bias,

with consistent definitions of clinical outcomes to consider the benefits of pharmacogenetic testing for

oncology.