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Per- and Polyfluoroalkyl Substances (PFAS), Epigenetic Age, and DNA Methylation: A Cross-Sectional Study of Firefighters

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posted on 21.10.2021, 08:20 authored by Jaclyn M. Goodrich, Miriam M. Calkins, Alberto J. Caban-Martinez, Todd Stueckle, Casey Grant, Antonia M. Calafat, Amy Nematollahi, Alesia M. Jung, Judith M. Graber, Timothy Jenkins, Angela L. Slitt, Alisa Dewald, Julianne Cook Botelho, Shawn Beitel, Sally Littau, John Gulotta, Darin Wallentine, Jeff Hughes, Charles Popp, Jefferey L. Burgess

Supplemental Table S1. Serum PFAS Concentrations (geometric means, ng/mL) by Categorical Demographic Variables

Supplemental Table S2. Significantly Differentially Methylated CpG Sites by PFAS Seum Concentration (at q-value<0.2)

Supplemental Table S3. Significantly Differentially Methylated Regions by PFAS Exposure

Supplemental Table S4. Pathways Enriched for Differential Methylation by PFAS Exposure

Supplemental Table S5. Association between Serum PFAS Concentrations (ln-transformed ng/mL) and Cell Type Estimates

Funding

National Institute of Environmental Health Sciences (NIEHS)

P30 Centers at the University of Arizona (grant no. P30 ES006694)

University of Michigan (grant no. P30 ES017885)

The US Federal Emergency Management Agency (FEMA) (grant no. EMW-2014-FP-00200, EMW-2015-FP-00213, and EMW-2018-FP-00086)

History