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Near-infrared enhances antiangiogenic potentiality of quinacrine-gold hybrid nanoparticles in breast cancer stem cells via deregulation of HSP-70/TGF-β - Supplementary data

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posted on 2023-03-14, 09:49 authored by Somya Ranjan Dash, Biswajit Das, Chinmay Das, Saptarshi Sinha, Subarno Paul, Rajalaxmi Pradhan, Chanakya Nath Kundu

Aim: This study aimed to explore the antiangiogenic mechanism of quinacrine-gold hybrid nanoparticle

(QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast cancer stem cells. Materials

& methods: Various cell-based in ovo angiogenesis and in vivo patient-derived xenograft mouse systems

were used as models for the study. Results: The experimental results showed that QAuNP + NIR

treatment deregulated the HSP-70/TGF-β physical interaction in primary breast cancer stem cells. Reduced

TGF-β secretion in the tumor microenvironment inhibited angiogenesis activation in endothelial cells

by deregulating the TGF-β-mediated PI3K/AKT/mTOR cascade. Conclusion: This study revealed that

QAuNP + NIR irradiation downregulated HSP-70 expression, inhibited the HSP-70/TGF-β interaction,

reduced the secretion of TGF-β in the tumor microenvironment and ultimately inhibited TGF-β-mediated angiogenesis.

Funding

This work was financially supported by the Department of Science and Technology (DST) INSPIRE and Indian Council of Medical Research (ICMR; ref no. 5/13/57/2015/-NCD-III).

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