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Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles - Supplementary dataset

Version 3 2023-01-17, 16:25
Version 2 2023-01-17, 10:58
Version 1 2023-01-17, 10:58
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posted on 2023-01-17, 16:25 authored by Yu-Ting Bai, Xue-Qiong Zhang, Xiao-Jie Chen, Gang Zhou

Oral cancer is a common life-threatening malignancy having high mortality and morbidity rates. During

the treatment process, individuals unavoidably experience severe side effects. It is essential to develop

safer and more effective strategies. Currently, extracellular vesicles (EVs) and biomimetic nanoparticles are

nanomedicines with long-term blood circulation and lower off-target toxicity that orchestrate immune

responses and accumulate specifically in tumor sites. EVs create a synergetic effect by encapsulating

drugs and collaborating with naturally loaded elements in the EVs. Biomimetic nanoparticles retain the

characteristic features of the synthetic nanocarriers and inherit the intrinsic cellmembrane functionalities.

This review outlines the properties, applications, challenges, pros and cons of EVs and biomimetic

nanoparticles, providing novel perspectives on oral cancer.

Funding

National Natural Science Foundation of China, (Grant / Award Number: ' 82101023,81970949,82270983')

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