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Multimodal molecular imaging in the second near-infrared window - Supplementary material

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posted on 2022-12-08, 10:29 authored by Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang, Xiao-Dong Zhang

Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of

physiological and pathological activities in living organisms with high spatiotemporal resolution. However,

the penetration depth of fluorescence restricts its ability to provide deep anatomical information.

Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and

magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and

quantitative information with deeper penetration by using multifunctional probes. This review offers

a comprehensive picture of NIR-II-based dual/multimodal imaging probes and highlights advances in

bioimaging and therapy. In addition, seminal studies and trends in multimodal imaging probes activated

by NIR-II laser are summarized and several key points regarding future clinical translation are elucidated.


National Natural Science Foundation of China, (Grant / Award Number: ' 91859101','11804248','81701826','81971673','81971744','82001952','U1932107')

Tianjin Health Research Project, (Grant / Award Number: 'TJWJ2021QN035','TJWJ2022MS010')

National Key Research and Development Program of China, (Grant / Award Number: '2021YFF1200700')

The Innovation Foundation of Tianjin University, and CAS Interdisciplinary Innovation Team, (Grant / Award Number: 'JCTD-2020-08')

National Natural Science Foundation of Tianjin, (Grant / Award Number: '19JCZDJC34000','20JCYBJC00940','21JCYBJC00490','21JCZDJC00620')

the Key Program of the Tianjin Health and Family Planning Commission, (Grant / Award Number: '16KG115')

Outstanding Youth Funds of Tianjin, (Grant / Award Number: '2021FJ-0009')


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