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Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women: supplementary data

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posted on 2023-04-17, 16:06 authored by Mostafa Salehi-Vaziri, Farzin Sadeghi, Hayedeh Haeri, Farah Bokharaei-Salim, Seyed Hamidreza Monavari, Firoozeh Sadat Hashemi, Somayeh Jalilvand, Hossein Keyvani

Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16)

and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16

variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage

was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical

intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical

cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based

on our data, the predominant HPV16 lineage was D and there was a significant association between

lineage D variants and cervical cancer.


This work was supported through a grant from the Iran University of Medical Sciences and Tehran University of Medical Sciences (project code: 92-01-30-21080).


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