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LMP1 encoded by Epstein–Barr virus mayactivate AHR through the ERK pathway innasopharyngeal carcinoma cells: supplementary files

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posted on 2023-08-08, 12:06 authored by Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, Bing Luo

Aim: To investigate the role of AHR in nasopharyngeal carcinoma (NPC) and explore the relationship

between Epstein–Barr virus (EBV) infection and the AHR pathway. Methods: The effect of LMP1 on the

expression of AHR was analyzed using real-time PCR and western blot. Proliferation and migration of cells

were assessed using CCK8 and Transwell analysis. Results: EBV infection downregulated the expression

of AHR in NPC cells, possibly through activation of the ERK pathway by LMP1 thereby accelerating

AHR proteasomal degradation following translocation to the nucleus. Cell proliferation, migration and

autophagy are promoted by activating the AHR pathway. Conclusion: In NPC cells, LMP1 increases the

phosphorylation of ERK, which may activate the AHR pathway.


This work was supported by The Clinical Medicine +X Project of the Affiliated Hospital of Qingdao University (grant no. QDFY + X202101023).