Future Science Group
Supplementary-appendix-for-NNM-2022-0092.docx (89.92 kB)

Insights into the mapping of green synthesis conditions for ZnO nanoparticles and their toxicokinetics - Supplementary appendix

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posted on 2022-10-18, 10:36 authored by Mo’tasem M Alsmadi, Nusaiba K Al-Nemrawi, Rana Obaidat, Anwar E Abu Alkahsi, Khetam M Korshed, Ishraq K Lahlouh

Research on ZnO nanoparticles (NPs) has broad medical applications. However, the green synthesis of ZnO

NPs involves a wide range of properties requiring optimization. ZnO NPs show toxicity at lower doses. This

toxicity is a function of NP properties and pharmacokinetics. Moreover, NP toxicity and pharmacokinetics

are affected by the species type and age of the animals tested. Physiologically based pharmacokinetic

(PBPK) modeling offers a mechanistic platform to scrutinize the colligative effect of the interplay between

these factors, which reduces the need for in vivo studies. This review provides a guide to choosing green

synthesis conditions that result in minimal toxicity using a mechanistic tool, namely PBPK modeling.