Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens - Supplementary Material
posted on 2023-03-09, 09:50authored byMartin Kr ´atk´y, Klara Konecna, Adela Simkova, Ondrej Jandourek, Jana Maixnerova, Jirina Stolarıkov, Marcela Vejsová, Barbora Voxová, Frantisek Trejtnar, Jarmila Vinsov
1H & 13C NMR spectra
Figure S1. Modification of salicylidene and heteroarylidene derivatives
Figure S2. Time-dependent interaction of 4d with VRSA at MIC and sub-MIC values
Figure S3. Time-dependent interaction of 4d with MRSA at MIC and sub-MIC values
Table S1. List of strains from the genus Staphylococcus and Enterococcus with their susceptibility/resistance profile used for extended study of antibacterial action within selected mafenide derivatives
Table S2. Activity of active mafenide derivatives 1-4 against Gram-negative bacteria
Table S3. Activity of the mafenide derivatives against drug-resistant TB strains
Funding
Univerzita Karlova v Praze, (Grant / Award Number: 'SVV 260 547') Grantová Agentura České Republiky, (Grant / Award Number: '20-19638Y') Ministerstvo Zdravotnictví Ceské Republiky, (Grant / Award Number: 'NU21-05-00482') European Commission, (Grant / Award Number: 'National Institute of virology and bacteriology [P')