Future Science Group
supplementary tables.pdf (2.06 MB)

Identification of RNA modification-associated single nucleotide polymorphisms in genomic loci for low-density lipoprotein cholesterol concentrations: Supplementary tables

Download (2.06 MB)
posted on 2022-07-26, 09:22 authored by Fan Tang, Chengcheng Duan, Ru Li, Huan Zhang, Xingbo Mo

Introduction: Genome-wide association studies have identified approximately 1000 lipid-associated loci,

but functional variants are less known. Materials & methods: The authors identified RNA modificationrelated

single nucleotide polymorphisms (RNAm-SNPs) in summary data from a genome-wide association

study. By applying Mendelian randomization analysis, the authors identified gene expression levels

involved in the regulation of RNAm-SNPs on low-density lipoprotein cholesterol (LDL-C) levels. Results:

The authors identified 391 RNAm-SNPs that were significantly associated with LDL-C levels. RNAm-SNPs

in NPC1L1, LDLR, APOB, MYLIP, LDLRAP1 and ABCA6 were identified. The RNAm-SNPs were associated

with gene expression. The expression levels of 112 genes were associated with LDL-C levels, and some of

them (e.g., APOB, SMARCA4 and SH2B3) were associated with coronary artery disease. Conclusion: This

study identified many RNAm-SNPs in LDL-C loci and elucidated the relationship among the SNPs, gene

expression and LDL-C.


The study was supported by the National Natural Science Foundation of China (82173597, 82073636, 81773508), the Startup Fund from Soochow University (Q413900313, Q413900412) and a project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.


Usage metrics