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Hyaluronic acid-engineered Bcl-2 inhibitor nanocrystals for site-specific delivery to breast tumor cells - supplementary table and figure

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posted on 2023-08-02, 09:54 authored by Dilip Panwar, Pradip Thakor, Madhu Sharma, Avijit Kumar Bakshi, Valamla Bhavana, Vaibhavi Srivastava, Prabhat Ranjan Mishra, Shashi Bala Singh, Neelesh Kumar Mehra

Aim: This investigation aims to repurpose venetoclax using hyaluronic acid-coated venetoclax nanocrystals (HA-VEN-NCs) to target breast cancer. Materials & methods: An antisolvent precipitation method was used to fabricate the nanocrystals and optimize them using central composite design. Hyaluronic acid (HA)-coated and -uncoated nanocrystals were compared in terms of in vitro drug release, cell line studies, CD44-expressing breast tumor cell binding capability and anticancer activity. Results: HA-VEN-NCs and venetoclax nanocrystals (VEN-NCs) showed pH-responsive drug-release behavior, exhibiting sustained release at pH 6.8. Our extensive in vitro cell line investigation showed that HA-VEN-NCs efficiently bind to CD44-expressing breast tumor cells and possess excellent anticancer activity (half maximal inhibitory concentration: 2.00 μg/ml) compared with VEN-NCs. Conclusion: Our findings anticipate that HA-VENNCs could serve as valuable nanoplatforms for cancer treatments in the future.

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