Future Science Group
Supplemental material.docx (146.21 kB)
Download file

Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial: Supplementary files

Download (146.21 kB)
posted on 2023-07-21, 10:20 authored by Jaclyn Kelly Mann, Tarylee Reddy, Mary van der Stok, Ayanda Ngubane, Takalani Mulaudzi, Nobuhle Mchunu, Portia Nevhungoni, Nithendra Manickchund, Pariva Manickchund, Chelline Helena Louise Cairns, Vaneshree Govender, Thumbi Ndung’u, Mahomed Yunus Suleman Moosa, Bernadett Isabel Gosnell

Aim: The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested

in a double-blind randomized control study. Methods: Adults with mild/moderate COVID-19, risk factors

for severe disease, and within 5 days of symptom onset were assigned to the intervention (n = 77) or

placebo (n = 79) arms. Symptoms were documented until day 42 post-enrollment and viral clearance was

assessed at 11–13 days post-symptom onset. Results: One participant developed severe COVID-19. The

severe-type symptom score was lower in the active arm at 11–13 days post-symptom onset (p = 0.049).

Chest pain, fever/chills, joint pain/malaise, and sore throat were significantly less frequent in the active

arm. No differences in viral clearance were observed. Conclusion: The intervention reduced symptoms of

mild/moderate COVID-19.


This research was funded by the Alliance for Accelerating Excellence in Science in Africa (AESA) platform at the African Academy of Sciences (AAS) (award no. SARSCoV2-3-20-006). Some staff assisting with the research were funded by the Victor Daitz Foundation.


Usage metrics

    Future Science OA