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Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review: supplementary tables

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posted on 2022-11-10, 13:18 authored by Corinne Duperrouzel, Coby Martin, Ari Mendell, Megan Bourque, Adam Carrera, Alicia Mack, Jeffrey Nesheim

Aim: To determine the economic burden associated with anticholinergic medication use in adults with

overactive bladder (OAB) in the USA. Methods: A systematic literature review was conducted to identify

articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in

adults with OAB. Results: From the 34 articles identified, increased anticholinergic burden, switching

anticholinergic treatments and potentially inappropriate anticholinergic use were associated with

increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to

individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and

costs. Conclusion: Additional controlled studies assessing the economic impact of anticholinergics in OAB

are needed and may enable optimization of economic and potentially patient outcomes.

Funding

This study was funded by Urovant Sciences (CA, USA). C Duperrouzel, C Martin and A Mendell were employees of EVERSANA™, a paid consultant of Urovant Sciences, at the time the analysis was conducted. M Bourque is an employee of EVERSANA™, a paid consultant of Urovant Sciences. A Carrera is an employee of Urovant Sciences and Duke Health. A Mack was an employee of Urovant Sciences at the time the work was conducted. J Nesheim is an employee of Urovant Sciences. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Medical writing and editorial support were provided by Joseph Kruempel, PhD, and Krystina Neuman, PhD, CMPP, of The Curry Rockefeller Group, LLC (NY, USA), and were funded by Urovant Sciences (CA, USA).

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    Journal of Comparative Effectiveness Research

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    Keywords

    anticholinergicanticholinergic burdenantimuscariniceconomic burdenHCRUhealthcare costshealthcare resource utilizationincontinenceoveractive bladderurology

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