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Genomic insights into extensively drug-resistant Pseudomonas aeruginosa isolated from a diarrhea case in Kolkata, India - Supplementary Figure 1

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posted on 2023-03-14, 11:18 authored by Goutam Chowdhury, Bhabatosh Das, Shakti Kumar, Archana Pant, Priyadarshini Mukherjee, Debjani Ghosh, Hemanta Koley, Shin-ichi Miyoshi, Keinosuke Okamoto, Alapan Paul, Shanta Dutta, Thandavarayan Ramamurthy, Asish K Mukhopadyay

Aim: To characterize extensively drug-resistant Pseudomonas aeruginosa from a patient with diarrhea. Materials & methods: Antimicrobial susceptibility was tested by the disk diffusion method. The P. aeruginosa genome was sequenced to identify virulence, antibiotic resistance and prophages encoding genes. Results: P. aeruginosa had a wide spectrum of resistance to antibiotics. Genomic analysis of P. aeruginosa revealed 76 genes associated with antimicrobial resistance, xenobiotic degradation and the type three secretion system. Conclusion: This is the first report on diarrhea associated with P. aeruginosa. Since no other organism was identified, the authors assume that the patient had dysbiosis due to antibiotic exposure, leading to antibiotic-associated diarrhea. The in vivo toxicity expressed by the pathogen may be associated with T3SS.

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