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Fungicidal and antibiofilm activities of gold nanoparticles on Candida tropicalis supplementary dataset

dataset
posted on 2022-12-14, 13:13 authored by Marıa Angel da Silva, Joaquın Calizto Garcıa-Martınez, Paulina Laura Paez, Marıa Gabriela Paraje

Aim: To investigate the antifungal activity of two different functionalized gold nanoparticles (AuNP),

those stabilized with cetyltrimethylammonium bromide and those conjugated with cysteine, and their

effects on the architecture of Candida tropicalis biofilms. Materials & methods: Biofilms were studied by

crystal violet binding assay and scanning electron microscopy. We investigated the effects of AuNPs on

reactive oxygen species, reactive nitrogen intermediates, and enzymatic and nonenzymatic antioxidant

defenses. Results/Conclusion: The fungicidal activity and cellular stress of both AuNPs affected biofilm

growth through accumulation of reactive oxygen species and reactive nitrogen intermediates. However,

cetyltrimethylammonium bromide-stabilized AuNPs revealed a higher redox imbalance.We correlated, for

the first time, AuNP effects with the redox imbalance and alterations in the architecture of C. tropicalis

biofilms.

Funding

Fondo para la Investigación Científica y Tecnológica, (Grant / Award Number: 'ANPCyT PICT')

Consejo Nacional de Investigaciones Científicas y Técnicas, (Grant / Award Number: 'PIP 2021/2023')

Secretaría de Ciencia y Tecnología Universidad Nacional de Córdoba, (Grant / Award Number: '411/2018')

Ministerio de Ciencia y Tecnología de la Provincia de Córdoba , (Grant / Award Number: '007')

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