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Efficacy and safety of nano-paclitaxel formulation for cancer treatment: evidence from randomized clinical trials supplementary files

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posted on 2023-05-24, 08:56 authored by Xiangmin Deng, Xiaoqin Huang, Xiaoyan Dong, Genxiang Mao, Wenmin Xing

Aim: We aimed to analyze efficacy and adverse events for nano-bound paclitaxel in cancer treatment,

which remain controversial. Method: We obtained relevant previously published studies and extracted

data on the efficacy and adverse events of nano-bound paclitaxel. Fifteen randomized clinical trials

were included. Results: Nanoparticle albumin-bound (Nab-) paclitaxel was beneficial in terms of objective

response rate (odds ratio [OR]: 1.08, 95% CI: 0.72–1.62) and partial response (OR: 1.28, 95% CI: 0.89–1.83),

while polymeric micellar (PM-) paclitaxel was beneficial in terms of objective response rate (OR: 1.76) and

partial disease (hazard ratio [HR]: 0.65). Both Nab-paclitaxel and PM-paclitaxel resulted in slightly longer

overall survival (HR: 0.93 and 0.94) and progression-free survival (HR: 0.93 and 0.87) when compared with

solvent-based paclitaxel. Peripheral sensory neuropathy (OR: 3.47), neutropenia (OR: 1.79) and anemia

(OR: 1.79) were more frequent after Nab-paclitaxel treatment. Conclusion: Nano-paclitaxel formulations

have a better efficacy in cancer treatment; however, they increase the risk of hematological adverse events

and peripheral sensory neuropathy. The PM-paclitaxel treatment had a high safety effect.

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