ESI: Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery - Supplementary dataset

<p>Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and</p> <p>treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were</p> <p>developed for these unmet needs. Methods: This study fabricated novel trifunctionalMNPs of Fe3O4@PLAPEG</p> <p>for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant</p> <p>loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g</p> <p>and significantly increased transverse relaxivity (r2 = 364.75 mM-1 s-1). The in vivo study confirmed that</p> <p>the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could</p> <p>effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential</p> <p>for drug release, cancer treatment monitoring and therapy.</p>