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EPI-2021-0133 Suppl. Data

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posted on 14.10.2021, 10:45 authored by Sonal Saxena, Sumana Choudhury, Pranay Amruth Maroju, Anuhya Anne, Lov Kumar, K. Naga Mohan

Supplementary Table 1. Primers used for COBRA, RT- and Copy Number- qPCRs.

Supplementary table 2: List of Log2 fold-change values of genes in Tet/Tet neurons and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 3: Gene ontology and pathway enrichment analysis of 1135 dysregulated genes in Tet/Tet neurons

Supplementary Table 4: Disease ontology of 1135 dysregulated genes in Tet/Tet neurons.

Supplementary Table 5: List of Log2 fold-change values of genes in Tet/Tet ESCs and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 6: Gene ontology and pathway enrichment analysis of 170 dysregulated genes in Tet/Tet ESCs.

Supplementary Table 7: Disease ontology of 170 dysregulated genes in

Tet/Tet ESCs.

Supplementary Table 8: List of Log2 fold-change values of genes in Tet/Tet ESCs, Tet/Tet neurons and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 9. List of imprinted genes showing dysregulation and hypomethylation in Tet/Tet neurons. Imprinted genes associated with Schizophrenia are shown in red.

Supplementary Table 10. Analysis of methylation of repeat elements in Tet/Tet ESCs. Total reads (hypermethylated + hypomethylated) less than 20 were not considered.

Supplementary Figure 1: COBRA assay of Snrpn, H19, Igf2r, IAP and LINE-1 elements. -: no enzyme control; +: reactions incubated with with Taqα1 (H19 and LINE-1) or HpyCH4IV (Snrpn, Igf2r and IAP). Presence of digested fragments indicates methylation. M- Marker

Funding

Scientific and Engineering Research Board (SERB) Government of India and OPERA (BITS Pilani)

Centre for Human Disease Research (BITS Pilani)

Department of Biotechnology, Government of India

Centre for Human Disease Research

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