Supplementary data_Merged file.pdf (1.17 MB)

EPI-2021-0133 Suppl. Data

dataset

posted on 2021-10-14, 10:45 authored by Sonal Saxena, Sumana Choudhury, Pranay Amruth Maroju, Anuhya Anne, Lov Kumar, K. Naga Mohan

Supplementary Table 1. Primers used for COBRA, RT- and Copy Number- qPCRs.

Supplementary table 2: List of Log2 fold-change values of genes in Tet/Tet neurons and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 3: Gene ontology and pathway enrichment analysis of 1135 dysregulated genes in Tet/Tet neurons

Supplementary Table 4: Disease ontology of 1135 dysregulated genes in Tet/Tet neurons.

Supplementary Table 5: List of Log2 fold-change values of genes in Tet/Tet ESCs and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 6: Gene ontology and pathway enrichment analysis of 170 dysregulated genes in Tet/Tet ESCs.

Supplementary Table 7: Disease ontology of 170 dysregulated genes in

Tet/Tet ESCs.

Supplementary Table 8: List of Log2 fold-change values of genes in Tet/Tet ESCs, Tet/Tet neurons and their corresponding values described by CommonMind Consortium (CMC), PsychENCODE and Brain Seq.

Supplementary Table 9. List of imprinted genes showing dysregulation and hypomethylation in Tet/Tet neurons. Imprinted genes associated with Schizophrenia are shown in red.

Supplementary Table 10. Analysis of methylation of repeat elements in Tet/Tet ESCs. Total reads (hypermethylated + hypomethylated) less than 20 were not considered.

Supplementary Figure 1: COBRA assay of Snrpn, H19, Igf2r, IAP and LINE-1 elements. -: no enzyme control; +: reactions incubated with with Taqα1 (H19 and LINE-1) or HpyCH4IV (Snrpn, Igf2r and IAP). Presence of digested fragments indicates methylation. M- Marker