Discovery of reversible selective MAO-B inhibitors with anti-AChE activity derived from 4-oxo-N, 4-diphenyl butanamides - Supplementary Material
Table S1. Docking results of 4-oxo-N, 4-diphenyl butanamides against AChE, and MAOs.
Table S2. Calculated physiochemical descriptors of 4-oxo-N, 4-diphenyl butanamides using QikProp
Table S3 Compound purity by HPLC (method):
Figure S1. HPLC Chromatogram (tR, 3.007 min) of compound 6h at 250 nm.
Table S4 Permeability of nine commercial drugs used for validation of PAMPA-BBB assay
Figure S2. Linear correlation chart of experimental and literature reported permeability of commercial drugs for PAMPA-BBB assay.
Table S5. Permeability of 4-oxo-N, 4-diphenyl butanamides determined by BBB-PAMPA assay
Table S6. Cell viability and neuroprotection of synthesized compounds on SH-SY5Y cell line
1H & 13C NMR spectra of Synthesised compounds: