Detection of relevant pharmacogenetic information through exome sequencing in oncology: Supplementary tables

Background: Germline sequencing of individual genomes can detect alleles responsible for adverse drug

reactions (ADRs) in relation to chemotherapy, targeted agents, antiemetics or pain treatment. Materials

& methods: To evaluate the interest of such pharmacogenetic information, the authors retrospectively

analyzed genes known to have an impact on cancer therapy in a cohort of 445 solid cancers patients.

Results: Six patients treated with 5-fluorouracil carrying one DPYD variant classified as 1A showed

decreased drug mean clearance (p = 0.01). Regarding CYP2D6, all patients (n = 5) with predicted CYP2D6

poor or ultra-rapid metabolizer status experienced adverse drug reactions related to opioid therapy.

Conclusion: Genomic germline sequencing performed for theragnostic issues in patients with a solid

tumor, can provide relevant information about common pharmacogenetic alleles.