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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II - Supplementary material
dataset
posted on 2023-01-18, 09:43 authored by Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Shi-Han Wu, Lu Chen, Jia-Zhen Wu, Zhen-Jiang Tong, Xiao-Long Wang, Xin Xue, Ning Ding, Xue-Jiao Leng, Liang Chang, Wei-Chen Dai, Yan-Cheng Yu, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao ShiSupporting information
Representative off-target/selective ligands
Chemistry
Compounds Information
Side chains
Target compounds
1H NMR and 13C NMR Spectra of Title Compounds
Table 1. Sequence identity (%, ATP binding site) between FLT3 and 328 other structural kinases that are gradually color-coded from green to orange to red. The ATP sites were defined according to KLIFS .
Table 2: Number of selective FLT3 inhibitors against 269 other kinases
