epi-2021-0205.xlsx (125.93 kB)
Download file

DEEP CHARACTERIZATION OF PAIRED CHROMATIN AND TRANSCRIPTOMES IN FOUR IMMUNE CELL TYPES FROM MULTIPLE SCLEROSIS PATIENTS

Download (125.93 kB)
dataset
posted on 22.10.2021, 10:07 authored by Figshare Future Science GroupFigshare Future Science Group, Sunjay Jude Fernandes, Matilda Ericsson, Mohsen Khademi, Maja Jagodic, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum, Jesper Tegnér

Supplementary Figure 1: Overview of the data analysis pipeline

Supplementary Figure 2: Volcano plots showing differentially expressed (DE) genes between HC and RR in CD4, CD8, CD14, and CD19. DE analysis was performed on all genes using linear models that, in addition to disease status, included age as a covariate (Methods). DE genes (FDR=0.2) have been highlighted with blue if upregulated in RR and red if downregulated in RR.

SUPPLEMENTARY TABLES:

Supplementary table 1: ATAC Seq differentially bound regions in all 4 cell types

Supplementary table 2: Transcription factor enrichment

Supplementary table 3: RNA Seq differentially expressed genes

Supplementary table 4: Correlation of differentially expressed and differentially bound regions

Funding

Astra Zeneca (AstraZeneca-Science for Life Laboratory collaboration) grant

EU FP7 306000 STATegra, King Abdullah University of Science and Technology

MultipleMS Horizon 2020 grant number 733161.

History