DEEP CHARACTERIZATION OF PAIRED CHROMATIN AND TRANSCRIPTOMES IN FOUR IMMUNE CELL TYPES FROM MULTIPLE SCLEROSIS PATIENTS
Supplementary Figure 1: Overview of the data analysis pipeline
Supplementary Figure 2: Volcano plots showing differentially expressed (DE) genes between HC and RR in CD4, CD8, CD14, and CD19. DE analysis was performed on all genes using linear models that, in addition to disease status, included age as a covariate (Methods). DE genes (FDR=0.2) have been highlighted with blue if upregulated in RR and red if downregulated in RR.
Supplementary table 1: ATAC Seq differentially bound regions in all 4 cell types
Supplementary table 2: Transcription factor enrichment
Supplementary table 3: RNA Seq differentially expressed genes
Supplementary table 4: Correlation of differentially expressed and differentially bound regions