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Supplementary_information_(NNM-2022-0191).docx (26.9 kB)

Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

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posted on 2022-10-07, 08:25 authored by Ying Zhang, Ruixing Liu, Chengcheng Li, Liuqi Shi, Zhihua Guo, Lei Zhu, Wen Li, Jingguo Li, Zhanrong Li

Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol

(celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials

& methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable

controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the

system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the

migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents epithelial–

mesenchymal transition in lens epithelial cells induced by TGF-β1 through the TGF-β1/Smad2/3/TEAD1

signaling pathway. In vivo efficiency evaluations showed that CMG demonstrated an excellent inhibitory

effect on PCO in rabbits and had no obvious tissue toxicity. Conclusion: Injectable CMG may represent

a promising ophthalmic platform for preventing PCO. This versatile injectable micelle–hydrogel hybrid

represents a clinically relevant platform to achieve localized therapy and controlled release of drugs in

other disease therapies.

Funding

National Natural Science Foundation of China, (Grant / Award Number: '52173143')

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