Cascade biomimetic intelligent nanotheranostic agents for imaging-guided tumor synergistic therapy - Supplementary data

Aim: Achieving drug-targeting delivery and environment-responsive releasing to realize imagingguided

precise tumor therapy. Materials & methods: Graphene oxide (GO) was used as the drugdelivery

system to load indocyanine green (ICG) and doxorubicin (DOX) to form a GO/ICG&DOX

nanoplatform, in which GO can quench the fluorescence of ICG and DOX. MnO2 and folate acidfunctionalized

erythrocyte membrane were further coated into the surface of GO/ICG&DOX to obtain

an FA-EM@MnO2-GO/ICG&DOX nanoplatform. Results: The FA-EM@MnO2-GO/ICG&DOX nanoplatform

has longer blood circulation time, precise targeting delivery to tumor tissues and catalase-like activity.

Both in vitro and in vivo results demonstrated that the FA-EM@MnO2-GO/ICG&DOX nanoplatform has

better therapeutic efficacy. Conclusion: The authors successfully fabricated a glutathione-responsive FAEM@

MnO2-GO/ICG&DOX nanoplatform, which can achieve drug-targeting delivery and precise drug

release.