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Benefits of dapagliflozin in the whole spectrum of heart failure in clinical practice: the RICA registry supplementary tables

posted on 2023-06-29, 10:19 authored by Manuel Montero-Perez-Barquero, Carlos Escobar-Cervantes, Meliton Francisco Davila-Ramos, Ivan Suarez-Pedreira, Jose Perez-Silvestre, Luis Miguel Ceresuela-Eito, Alberto Muela-Molinero, Marıa Angustias Quesada-Simon, Francesc Formiga, Alvaro Gonzalez-Franco, Jesus Casado-Cerrada

Aims: To determine the projected benefits of dapagliflozin after an acute heart failure (HF) event in

Spain. Methods: A multicenter and prospective study that included subjects aged 50 years or older

consecutively admitted with HF to internal medicine departments in Spain. The projected clinical benefits

of dapagliflozin were calculated via pooled analysis of the DAPA-HF and DELIVER trials. Results: A total

of 5644 subjects were analyzed, of whom 79.2% were eligible for dapagliflozin, according to criteria

of the DAPA-HF and DELIVER trials. Full implementation of dapagliflozin would imply a 1-year absolute

risk reduction of 2.3% for death (number needed to treat = 43) and 5.7% (number needed to treat = 17)

for HF rehospitalization. Conclusion: Treatment with dapagliflozin could significantly reduce HF burden

in clinical practice.