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Association between human Epstein–Barr virus and brain cancer: a systematic review and meta-analysis – Supplementary files

posted on 2023-06-05, 10:58 authored by Saied Ghorbani, Vahid Tambrchi, Rana Farzi, Alireza Khatami, Rahil Nahid Samiei, Hassan Saadati, Maryam Noori, Arash Letafati, Atefeh Bahavar, Noorin Hezarpishe, Mehrshid Musavioun, Bahareh Mirzaei, Mohadeseh Sadat Meftagh, Najme Khodaei Doust, Fatemeh Hejami, Seyed Jalal Kiani

Aim: The aim of this study was to investigate the pooled prevalence and potential correlation between

Epstein–Barr virus (EBV) infection and brain cancers. Materials & methods: We searched for relevant

studies in main databases and analyzed the heterogeneity, odds ratio and corresponding 95% CI among

all studies using STATA software V.14. Results: Fourteen articles were included in the meta-analysis.

The pooled prevalence of EBV among brain cancer patients was 9% (95% CI: 3–16%; I2 = 91.06%).

An association was found between EBV and brain cancer (OR: 6.90 [95% CI: 1.81–26.28]; I2 = 0%]).

Conclusion: The results of this study indicate a significant association between EBV infection and brain

cancer, suggesting EBV infection is a potential risk factor for brain cancer development.


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