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Antibacterial and anticancer activities of green-synthesized silver nanoparticles using Photinia glabra fruit extract

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posted on 2023-08-10, 09:51 authored by Tabbisa Namulinda, Lei-Lei Bao, Justus Kwetegyeka, Ivan Gumula, Yi-Jia Yan, Zhi-Long Chen

Aims: We prepared Photinia glabra (PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated the antibacterial and anticancer activities of the nanoparticles (NPs). Materials & methods: Silver nitrate aqueous solution was reduced to PG-Ag NPs using aqueous PG fruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infrared and x-ray diffraction. Results & conclusions: PG-Ag NPs were spherical, approximately 39–77 nm-sized, furctionalized surfaces with notable antibacterial activity against both Escherichia coli and Staphylococcus aureus, with an MIC <30 ug/ml and cytotoxicity toward esophageal cancer cells, with IC50 values less than 20 ug/ml. PGAg@ rt NPs have been shown to be a potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.

Funding

Foundation of Shanghai Science and Technology Committee, (Grant / Award Number: '20430730900','20490740400','21430730100','23S11901600')

Grant of Dongfang Hepatobiliary Surgery Hospital, (Grant / Award Number: '2019-539','20WQ011')

National Natural Science Foundation of China, (Grant / Award Number: '21977016')

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