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ABCB1 and OPRM1 single-nucleotide polymorphisms collectively modulate chronic shoulder pain and dysfunction in South African breast cancer survivors: supplementary data

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posted on 2022-06-21, 08:30 authored by Firzana Firfirey, Alison V September, Delva Shamley

Background: Chronic shoulder pain/disability is a well-recognized side effect of treatment for breast

cancer, with ∼40% of patients experiencing this, despite receiving pain management. To manage acute

and chronic pain, several opioids are commonly prescribed. Pharmacogenomics have implicated genes

within the opioid signaling pathway, including ABCB1 and OPRM1, to contribute to an individual’s variable

response to opioids. Aim: To evaluate ABCB1 (rs1045642 G>A, rs1128503 G>A) and OPRM1 (rs1799971

A>G, rs540825 T>A) single-nucleotide polymorphisms (SNPs) in chronic shoulder pain/disability in BCS.

Funding

University of Cape Town (WUN scholarship and Foundation Contingency award)

National Research Foundations (grant no. 102470), South Africa

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