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3’UTR variants in DEFA5 gene associated with Immunoglobulin A nephropathy susceptibility in the Chinese Han population - Supplementary Table 1

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posted on 2023-01-12, 10:19 authored by Hongwei Peng, Pingyun Fan, Yifeng HongYifeng Hong, Jing HeJing He, Xiangxiu Zeng, Fengguo Xu, yunxia zhao, Tianbo JinTianbo Jin

Aim: To evaluate the association between single-nucleotide polymorphisms in the 3? untranslated region

of the DEFA5 gene and IgA nephropathy (IgAN) risk, the authors performed an association study in the

Chinese Han population. Materials & methods: The authors recruited 426 IgAN patients and 498 controls.

The MassARRAY platform (Agena Bioscience, Inc., CA, USA) was used to genotype single-nucleotide

polymorphisms in DEFA5. Odds ratios and 95% CIs were calculated through logistic regression analysis.

Results: The authors observed that rs12716641 significantly reduced IgAN risk in the allele (odds ratio:

0.77; p = 0.026) and genotype (odds ratio: 0.75; p = 0.039) models. Stratification analysis revealed that

several genotypes of rs12716641 played a protective role against IgAN. Conclusion: The authors’ results

revealed that single-nucleotide polymorphisms in the 3? untranslated region of DEFA5 were associated

with IgAN risk.