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FMC-Supplementary-data.docx (10.94 MB)

2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and Plasmodium falciparum inhibitory activity - Supplementary data

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posted on 2022-11-09, 10:06 authored by Amanda Berg, Chelsea B Swartchick, Noah Forrest, Matthew Chavarria, Madeleine C. Deem, Alyson N Sillin, Yuexin Li, Teresa M Riscoe, Aaron Nilsen, Michael K. Riscoe, Warren JL Wood

 Synthesis of 4-hydroxyphenyl esters 20c and 20d 

 General method for the synthesis of the phenoxyphenyl esters (22a-d)  

 General method for the synthesis of the phenoxyphenyl acids (23a-d) 

 Characterization of 3b, 3c, and 3g-j  

 Ester reduction to synthesize 28a and 28b 

 Carboxylic acid reduction to synthesize 2-(4-(4-fluorophenoxy)phenyl)ethan-1-ol (28c) 

 Further information from the oxidation and reductive alkylation reactions to obtain 3h, 3i, and 3k  

 Parasite culture and assay information  


 1H and 13C NMR spectra for all compounds 


M.J. Murdock Charitable Trust, (Grant / Award Number: 'Murdock College Research Program for Natural Scien') U.S. Department of Veterans Affairs, (Grant / Award Number: 'i01 BX003312 ') National Institute of Allergy and Infectious Diseases, (Grant / Award Number: 'R01AI100569','R01AI141412') U.S. Department of Defense, (Grant / Award Number: 'Log # PR181134') VA Research Career Scientist Award, (Grant / Award Number: '14S-RCS001')