Supplementary Figure 1. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors

Supplementary Figure 1. PpIX and BPD induce ROS generation.
(a) PpIX and BPD generated ROS in Panc1 cells as assessed by HE staining. Pre-treatment with 4 μM resveratrol reverted the effect of these compounds. Representative histograms of three independent experiments are shown.
(b) Neither, PpIX nor BPD induced ROS in non-transformed HPDE cells (DCFDA staining). H2O2 treatment was used as positive control of ROS induction. The representative histograms are shown (n=3).