Predictive value and clinical significance of increased SSAT-1 activity in healthy adults: graphical abstract
Paramjit S Tappia
Andrew W Maksymiuk
Daniel S Sitar
Parveen S Akhtar
Nazrina Khatun
Rahnuma Parveen
Rashiduzzaman Ahmed
Rashid Bux Ahmed
Brian Cheng
Gina Huang
Horacio Bach
Brett Hiebert
Bram Ramjiawan
10.25402/FSOA.8397095.v2
https://future-science-group.figshare.com/articles/figure/Predictive_value_and_clinical_significance_of_increased_SSAT-1_activity_in_healthy_adults_graphical_abstract/8397095
Graphical Abstract. <div>Aim: Spermidine/spermine N1-acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA). Although SSAT-1 is activated in patients with cancer, a number of ostensibly healthy adult volunteers had higher than expected AA concentration. This study was undertaken to examine the outlier group. Results: In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent pre-malignant conditions. Hematology tests revealed elevations in white blood cells and platelets which are markers of inflammation. Conclusion: High urine concentration of AA could be used as a simple and useful test for screening of cancer in high risk populations. <div>
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2019-07-01 12:57:19
Biomarkers
SSAT-1
Amantadine
Cancer screening and diagnostics
Early detection
Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
Clinical Chemistry (diagnostics)
Cancer Diagnosis