Acedo, Pilar Fernandes, Aristi Zawacka-Pankau, Joanna Supplementary Figure 1. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors <div><b>Supplementary Figure 1. PpIX and BPD induce ROS generation.</b></div><div>(a) PpIX and BPD generated ROS in Panc1 cells as assessed by HE staining. Pre-treatment with 4 μM resveratrol reverted the effect of these compounds. Representative histograms of three independent experiments are shown.</div><div>(b) Neither, PpIX nor BPD induced ROS in non-transformed HPDE cells (DCFDA staining). H2O2 treatment was used as positive control of ROS induction. The representative histograms are shown (n=3). </div><div><br></div> Apoptosis;benzoporphyrin derivative;drug repurposing;mutant p53;pancreatic cancer;protoporphyrin IX;ROS;TAp73;thioredoxin reductase;Cancer Cell Biology;Cancer Therapy (excl. Chemotherapy and Radiation Therapy);Clinical Pharmacology and Therapeutics 2019-03-21
    https://future-science-group.figshare.com/articles/figure/Supplementary_Figure_1_Activation_of_TAp73_and_inhibition_of_TrxR_by_Verteporfin_for_improved_cancer_therapy_in_TP53_mutant_pancreatic_tumors_supplementary_material/7873430
10.25402/FSOA.7873430.v2