%0 Figure %A Acedo, Pilar %A Fernandes, Aristi %A Zawacka-Pankau, Joanna %D 2019 %T Supplementary Figure 1. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors %U https://future-science-group.figshare.com/articles/figure/Supplementary_Figure_1_Activation_of_TAp73_and_inhibition_of_TrxR_by_Verteporfin_for_improved_cancer_therapy_in_TP53_mutant_pancreatic_tumors_supplementary_material/7873430 %R 10.25402/FSOA.7873430.v2 %2 https://future-science-group.figshare.com/ndownloader/files/14659181 %K Apoptosis %K benzoporphyrin derivative %K drug repurposing %K mutant p53 %K pancreatic cancer %K protoporphyrin IX %K ROS %K TAp73 %K thioredoxin reductase %K Cancer Cell Biology %K Cancer Therapy (excl. Chemotherapy and Radiation Therapy) %K Clinical Pharmacology and Therapeutics %X
Supplementary Figure 1. PpIX and BPD induce ROS generation.
(a) PpIX and BPD generated ROS in Panc1 cells as assessed by HE staining. Pre-treatment with 4 μM resveratrol reverted the effect of these compounds. Representative histograms of three independent experiments are shown.
(b) Neither, PpIX nor BPD induced ROS in non-transformed HPDE cells (DCFDA staining). H2O2 treatment was used as positive control of ROS induction. The representative histograms are shown (n=3).

%I Future Science Group