%0 Figure %A Li, Zhi %A Zilberman, Yael %A Lu, Qing-Bin %A Tang, Xiaowu (Shirley) %D 2019 %T Supplementary figure S6. Electrochemical methods for probing DNA damage mechanisms and designing cisplatin-based combination chemotherapy %U https://future-science-group.figshare.com/articles/figure/Supplementary_figure_S6_Electrochemical_methods_for_probing_DNA_damage_mechanisms_and_designing_cisplatin-based_combination_chemotherapy/7869272 %R 10.25402/BTN.7869272.v1 %2 https://future-science-group.figshare.com/ndownloader/files/14653415 %K Cisplatin %K combination therapy %K DNA damage %K electrochemical analysis %K reduced graphene oxide %K Chemotherapy %K Cancer Cell Biology %X
Figure S6. The effect of PEG-rGO on DNA damage. CV curves of 500 µM dGMP mixed with 500 µM cisplatin and (a) 0.15 mg/ml, (b) 0.75 mg/ml PEG-rGO at various time points (scan rate: 20 mV/s). (c) Oxidation peak values. (d) Reaction kinetics study of 500 µM dGMP mixed with 500 µM cisplatin, 500 µM Cisplatin+ 0.15 mg/ml PEG-rGO and 500 µM CDDP+ 0.75 mg/ml PEG-rGO over time.

Figure S6 shows that the reaction rate remained unchanged with the introduction of PEG-rGO. Therefore the conclusion is that PEG-rGO doesn’t promote dGMP damage.

%I Future Science Group